反应详情

0.1 mol of crude 3-oxo-butyric acid 4-cyclohexylpiperazide is dissolved in 150 ml of tetrahydrofuran and, under reflux, after addition of 0.5 g of p-toluenesulphonic acid, ammonia is passed in for 4 hours. The mixture is allowed to stand at room temperature overnight, the solvent is removed by distillation in vacuo, and the residue is crystallized from toluene/petroleum ether.

1. temperatureunder reflux
2. customis passed in for 4 hours
3. customthe solvent is removed by distillation in vacuo
4. customthe residue is crystallized from toluene/petroleum ether