Ammonia → HCID 86742239, compound

HRID 580511Notes

Reaction equation

HRID 580511 reaction equation
[CH:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:18])[CH2:14][C:15](=O)[CH3:16])[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(C)C=CC(S(O)(=O)=O)=CC=1.[NH3:30]>O1CCCC1>[CH:1]1([N:7]2[CH2:12][CH2:11][N:10]([C:13](=[O:18])/[CH:14]=[C:15](\[NH2:30])/[CH3:16])[CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6101p-Toluenesulfonic acidHCID 861624823-Oxo-butyric acid 4-cyclohexylpiperazide

Product 1

HCID 86742239HCID 86742239, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.1 mol of crude 3-oxo-butyric acid 4-cyclohexylpiperazide is dissolved in 150 ml of tetrahydrofuran and, under reflux, after addition of 0.5 g of p-toluenesulphonic acid, ammonia is passed in for 4 hours. The mixture is allowed to stand at room temperature overnight, the solvent is removed by distillation in vacuo, and the residue is crystallized from toluene/petroleum ether.

Workup

  1. temperatureunder reflux
  2. customis passed in for 4 hours
  3. customthe solvent is removed by distillation in vacuo
  4. customthe residue is crystallized from toluene/petroleum ether

Sources & evidence

ORD record
ord-0175a7ef9dff4529ae0f906735ed263f
Source dataset
uspto-grants-1988_06
Patent number
US04753936

Reaction notes

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