HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Propanone, 1-nitro- → 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)-pyridine-3-carboxylic acid 4-cyclohexylpiperazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Propanone, 1-nitro- | HCID 66296 | — |
| Reactant | 2'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbaldehyde | HCID 1392725 | — |
| Reactant | HCID 86742239 | HCID 86742239 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)-pyridine-3-carboxylic acid 4-cyclohexylpiperazide | HCID 86742240 | — |
Reaction Steps
17.4 g (0.10 mol) of 2-trifluoromethylphenylbenzaldehyde, 12.0 g (0.12 mol) of nitroacetone and 25.1 g (0.10 mol) of β-aminocrotonic acid 4-cyclohexylpiperazide are heated in 50 ml of isopropanol at 60° C. for 12 hours. On cooling, the product separates out and is recrystallized from isopropanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04753936 |
| Source dataset | uspto-grants-1988_06 |
| ORD ID | ord-e7e4f18f80774170914c3b019461fcf8 |
| Source note | uspto-grants-1988_06 |