Ammonium Hydroxide → 5-Bromopyridine-2-sulfonamide

HRID 58053Notes

Reaction equation

HRID 58053 reaction equation
Cl.[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9](Cl)(=[O:11])=[O:10])=[N:7][CH:8]=1.[OH-].[NH4+:14]>>[Br:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([NH2:14])(=[O:11])=[O:10])=[N:7][CH:8]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 467388875-Bromopyridine-2-sulfonyl chloride, HCl

Product 1

HCID 509897865-Bromopyridine-2-sulfonamide

Conditions

Temperature
70 °C

Procedure

To a 4 mL vial equipped with a magnetic stir bar were added 5-bromopyridine-2-sulfonyl chloride hydrochloride (250 mg, 0.853 mmol) and ammonium hydroxide (1329 μL, 34.1 mmol) to give a white suspension, which was heated to 70° C. in a sand bath overnight. The solvent was subsequently evaporated to give the title compound, which was used without further purification.

Workup

  1. customTo a 4 mL vial equipped with a magnetic stir bar
  2. customto give a white suspension, which
  3. customThe solvent was subsequently evaporated

Sources & evidence

ORD record
ord-079c2d860f624468a24d1ac13482ea9b
Source dataset
uspto-grants-2016_09
Patent number
US09434743B2

Reaction notes

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