Ammonia → HCID 14207944, compound

HRID 580532Notes

Reaction equation

HRID 580532 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]2[S:11][CH:12]=[CH:13][C:3]=12.[NH3:14]>CC(O)C>[NH2:14][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][N:5]=[C:4]2[S:11][CH:12]=[CH:13][C:3]=12

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14207943HCID 14207943, compound

Product 1

HCID 14207944HCID 14207944, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a stirred suspension of 3.35 g of 4-chloro-5-nitrothieno[2,3-b]pyridine 7 in 160 ml of 2-propanol is introduced excess amount of anhydrous ammonia at 45°-50° C. during 4 hours. After removal of the solvent, the residue is suspended in water. The solid is washed with water and cold ether, affording 2.65 g (87%) of Compound 8 as crystals. Recrystallization from methanol-ether gives a pure sample melting at 227°-228.5° C.

Workup

  1. customAfter removal of the solvent
  2. washThe solid is washed with water and cold ether

Sources & evidence

ORD record
ord-0ca377d8b70c4b1ca051ab14b85d0c11
Source dataset
uspto-grants-1988_06
Patent number
US04753951

Reaction notes

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