Ammonia → HCID 14207948, compound

Participants

Reaction Steps

To a stirred suspension of 1.25 g of 4-chloro-3-nitrothieno[3,4-b]pyridine 11 in 37 ml of 2-propanol is introduced anhydrous ammonia at room temperature during 3 hours. The mixture is concentrated in vacuo and the residue is suspended in water with stirring. The crystals are collected by filtration, washed with water and dried to give 1.09 g (96%) of Compound 12. An analytical sample is recrystallized from chloroform-methanol, giving yellow crystals melting at 307°-309° C.

Provenance & Evidence