Ammonia → HCID 14207948, compound

HRID 580535Notes

Reaction equation

HRID 580535 reaction equation
Cl[C:2]1[C:3]2[C:4](=[CH:11][S:12][CH:13]=2)[N:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH3:14]>CC(O)C>[NH2:14][C:2]1[C:3]2[C:4](=[CH:11][S:12][CH:13]=2)[N:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 14207947HCID 14207947, compound

Product 1

HCID 14207948HCID 14207948, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a stirred suspension of 1.25 g of 4-chloro-3-nitrothieno[3,4-b]pyridine 11 in 37 ml of 2-propanol is introduced anhydrous ammonia at room temperature during 3 hours. The mixture is concentrated in vacuo and the residue is suspended in water with stirring. The crystals are collected by filtration, washed with water and dried to give 1.09 g (96%) of Compound 12. An analytical sample is recrystallized from chloroform-methanol, giving yellow crystals melting at 307°-309° C.

Workup

  1. concentrationThe mixture is concentrated in vacuo
  2. filtrationThe crystals are collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-3deb8df9108b41908f4d32618c48db5f
Source dataset
uspto-grants-1988_06
Patent number
US04753951

Reaction notes

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