Sodium Methoxide → HCID 20133950, compound

HRID 580541Notes

Reaction equation

HRID 580541 reaction equation
[CH3:1][O-:2].[Na+].[CH3:4][N:5]1[C:12](=[O:13])[CH:11]([C:14](=[O:30])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]3[N:24]=[N:25][C:26](Cl)=[CH:27][CH:28]=3)=[CH:18][CH:17]=2)[C:9](=[O:10])[N:8]([CH3:31])[C:6]1=[O:7]>CO.O>[CH3:4][N:5]1[C:12](=[O:13])[CH:11]([C:14](=[O:30])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([O:22][C:23]3[N:24]=[N:25][C:26]([O:2][CH3:1])=[CH:27][CH:28]=3)=[CH:18][CH:17]=2)[C:9](=[O:10])[N:8]([CH3:31])[C:6]1=[O:7]

Participants

5

Reactant 2

HCID 10942334Sodium MethoxideHCID 20133960HCID 20133960, compound

Product 1

HCID 20133950HCID 20133950, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

The equimolar amount of sodium methylate is added at room temperature to 1.0 g (0.0025 mole) of 1,3-dimethyl-5-[4-(6-chloropyridazin-3-yloxy)phenylcarbamoyl]barbituric acid in 20 ml of methanol. The mixture is heated under reflux for 5 hours, then cooled, diluted with water and filtered. The filtrate is washed with water and dried.

Workup

  1. temperatureThe mixture is heated
  2. temperatureunder reflux for 5 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. washThe filtrate is washed with water
  6. customdried

Sources & evidence

ORD record
ord-fa57ca4cc81d4453b454e3d3f4070a94
Source dataset
uspto-grants-1988_06
Patent number
US04753940

Reaction notes

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