1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → HCID 20133968, compound

HRID 580542Notes

Reaction equation

HRID 580542 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:18]=[CH:17][C:15]([NH2:16])=[CH:14][CH:13]=1.[CH3:19][N:20]1[C:27](=[O:28])[CH:26]([C:29](OCC)=[O:30])[C:24](=[O:25])[N:23]([CH3:34])[C:21]1=[O:22]>C1(C)C=CC=CC=1>[CH3:34][N:23]1[C:24](=[O:25])[CH:26]([C:29](=[O:30])[NH:16][C:15]2[CH:14]=[CH:13][C:12]([O:11][C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=3)=[CH:18][CH:17]=2)[C:27](=[O:28])[N:20]([CH3:19])[C:21]1=[O:22]

Participants

4

Reactant 2

HCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 131089464-(Quinolin-2-yloxy)aniline

Product 1

HCID 20133968HCID 20133968, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

6.1 g of 4-(quinolin-2-yloxy)aniline and 5.8 g of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid are heated under reflux in 50 ml of toluene. When the temperature is at 80° C., a thick crystalline slurry is formed which at 120° C. is again of a stirrable consistency. After stirring for 3 hours, the mixture is cooled and the crystals are isolated by suction filtration.

Workup

  1. customis at 80° C.
  2. customa thick crystalline slurry is formed which at 120° C.
  3. temperaturethe mixture is cooled
  4. customthe crystals are isolated by suction filtration

Sources & evidence

ORD record
ord-5f781abe18c04b42b6b239bd41b0c6b4
Source dataset
uspto-grants-1988_06
Patent number
US04753940

Reaction notes

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