反应详情

In a 4 mL vial equipped with a magnetic stir bar were combined 5-bromopyridine-2-sulfonyl chloride hydrochloride (50 mg, 0.171 mmol), 2-aminoethanol (0.015 mL, 0.256 mmol), Et3N (0.071 mL, 0.512 mmol), and acetonitrile (1 mL). The resulting yellow solution stirred at room temperature overnight. The reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL). The layers were separated and the aqueous layer was back-extracted with ethyl acetate (15 mL). The combined organic layers were concentrated to give the title compound as a clear liquid, which was used without further purification (55 mg).

1. customIn a 4 mL vial equipped with a magnetic stir bar
2. customThe reaction mixture was subsequently partitioned between water (10 mL) and ethyl acetate (15 mL)
3. customThe layers were separated
4. extractionthe aqueous layer was back-extracted with ethyl acetate (15 mL)
5. concentrationThe combined organic layers were concentrated