反应详情

A mixture of 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.5 g), anhydrous acetonitrile (5 ml), 3-t-butoxycarbonylamino-4-methylpyrrolidine (0.53 g) and DBU (0.27 g) was refluxed for an hour. After cooling in a refrigerator, the resulting precipitate was collected by filtration and washed with acetonitrile and ether successively to give the title compound (0.32 g) as pale yellow powder, mp 230°-231° C.

1. temperaturewas refluxed for an hour
2. temperatureAfter cooling in a refrigerator
3. filtrationthe resulting precipitate was collected by filtration
4. washwashed with acetonitrile and ether successively