反应详情

A mixture of 7-(cis-3-t-butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.3 g) in ethanol (5 ml) and ethanolic hydrochloride (6 ml) was stirred for 2 hours at room temperature and then concentrated. To the residue was added ethanol and the resulting precipitate was collected by filtration and washed with ethanol to give the title compound (0.21 g) as pale yellowish powder, mp 274°-275° C. (decompd.).

1. concentrationconcentrated
2. additionTo the residue was added ethanol
3. filtrationthe resulting precipitate was collected by filtration
4. washwashed with ethanol