Ammonia → HCID 86742250, compound

HRID 580591Notes

Reaction equation

HRID 580591 reaction equation
C(OC([NH:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:24]([Cl:25])=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3[CH2:26][CH2:27][F:28])=[CH:17][C:16]=2[F:33])[CH2:10]1)=O)(C)(C)C.N>CO.Cl>[NH2:8][C@H:9]1[C@@H:13]([CH3:14])[CH2:12][N:11]([C:15]2[C:24]([Cl:25])=[C:23]3[C:18]([C:19](=[O:32])[C:20]([C:29]([OH:31])=[O:30])=[CH:21][N:22]3[CH2:26][CH2:27][F:28])=[CH:17][C:16]=2[F:33])[CH2:10]1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 86742251HCID 86742251, compound

Product 1

HCID 86742250HCID 86742250, compoundYield 48.4%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A mixture of 7-(cis-3-t-butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-8-chloro-6-fluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (0.13 g) in methanol (1.5 ml) and concentrated hydrochloric acid (1.5 ml) was stirred at room temperature for 30 minutes. The reacting mixture was neutralized with concentrated aqueous ammonia and then cooled. The resulting precipitate was collected by filtration and washed with water, methanol and ether successively to give the title compound (0.05 g) as pale yellow powder, mp 234°-236° C. (decompd.).

Workup

  1. temperaturecooled
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water, methanol and ether successively

Sources & evidence

ORD record
ord-d5b7e23f7fa74c33b9e463868fbaeef6
Source dataset
uspto-grants-1988_06
Patent number
US04753953

Reaction notes

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