Morpholine → HCID 53713607, compound

HRID 580609Notes

Reaction equation

HRID 580609 reaction equation
[NH2:1][C:2]1[C:18]([Br:19])=[CH:17][C:5]([C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][C:8]([OH:10])=O)=[CH:4][C:3]=1[Br:20].ClC(OCC)=O.[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>C(N(CC)CC)C>[NH2:1][C:2]1[C:3]([Br:20])=[CH:4][C:5]([C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:7][C:8]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:10])=[CH:17][C:18]=1[Br:19]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 10928Ethyl chloroformateHCID 54047298HCID 54047298, compound

Product 1

HCID 53713607HCID 53713607, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

This compound was prepared from 4-amino-3,5-dibromo-β-phenyl-cinnamic acid (isomer ratio A:B=1:1), ethyl chloroformate, triethylamine and morpholine analogous to Example 1(c). Melting point of the 1:1 mixture of isomers A and B: 156°-174° C.

Workup

  1. additionMelting point of the 1:1 mixture of isomers A and B
  2. custom156°-174° C.

Sources & evidence

ORD record
ord-bcd23869f3884a96995b7c4ba691394c
Source dataset
uspto-grants-1988_06
Patent number
US04753934

Reaction notes

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