Morpholine → HCID 54436543, compound

HRID 580611Notes

Reaction equation

HRID 580611 reaction equation
[NH2:1][C:2]1[C:19]([Cl:20])=[CH:18][C:5]([C:6]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:7][C:8]([OH:10])=O)=[CH:4][C:3]=1[Cl:21].ClC(OCC)=O.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>C(N(CC)CC)C>[NH2:1][C:2]1[C:3]([Cl:21])=[CH:4][C:5]([C:6]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[CH:7][C:8]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)=[O:10])=[CH:18][C:19]=1[Cl:20]

Participants

5

Reactant 3

HCID 8083MorpholineHCID 10928Ethyl chloroformateHCID 54462647HCID 54462647, compound

Product 1

HCID 54436543HCID 54436543, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

This compound was prepared from 4-amino-3,5-dichloro-β-(4'-fluorophenyl)-cinnamic acid (isomer ratio A:B=3:1), ethyl chloroformate, triethylamine and morpholine analogous to Example 1(c).

Sources & evidence

ORD record
ord-ab2f4e494a584a65a6c7e6976f5d984e
Source dataset
uspto-grants-1988_06
Patent number
US04753934

Reaction notes

Loading…