反应详情

To 6-methoxy-5-(6-(trifluoromethyl)-1H-indazol-4-yl)picolinonitrile (0.5 g, 1.571 mmol) in EtOH (20 mL) was added sodium hydroxide (3.93 mL, 7.86 mmol). The reaction mixture was stirred for 50 minutes at reflux and was subsequently diluted with water and acidified with concentrated HCl. The volatiles were evaporated and the residue was purified by preparative HPLC, eluting with 45% acetonitrile (containing 0.035% TFA) in H2O (containing 0.05% TFA) over a period of 4 minutes. The product-containing fractions were combined and the volatiles removed by rotary evaporation to give the title compound.

1. temperatureat reflux
2. customThe volatiles were evaporated
3. customthe residue was purified by preparative HPLC
4. washeluting with 45% acetonitrile (containing 0.035% TFA) in H2O (containing 0.05% TFA) over a period of 4 minutes
5. customthe volatiles removed by rotary evaporation