反应详情

A mixture of (S)-6-(4-aminophenyl)-5-methyl-4,5-dihydro-3(2H)-pyridazinone (147 mg), 4H-pyran-4-one (78 mg) and hydrochloric acid (0.1N, 1.5 ml) in water (2 ml) was stirred under reflux under nitrogen for 3 hours. The reaction mixture was cooled to afford the title compound, which was collected, washed with water and dried, 110 mg, m.p. 256°-7° C. (softens 80° C.), [α]D25 =+354° (1.03% in dimethylformamide).

1. temperatureunder reflux under nitrogen for 3 hours
2. temperatureThe reaction mixture was cooled