HCID 67689969, compound → HCID 54308048, compound

HRID 580849Notes

Reaction equation

HRID 580849 reaction equation
C(OC([N:8]1[C:12]2=[CH:13][N:14]=[C:15]([N:17]3[CH:21]=[N:20][CH:19]=[N:18]3)[CH:16]=[C:11]2[C:10]([CH:22]=[CH:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[CH:9]1)=O)(C)(C)C.[H][H]>[Pd].C(O)C>[N:17]1([C:15]2[CH:16]=[C:11]3[CH:10]([CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[CH2:9][NH:8][C:12]3=[CH:13][N:14]=2)[CH:21]=[N:20][CH:19]=[N:18]1

Participants

5

Reactant 2

HCID 67689969HCID 67689969, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 54308048HCID 54308048, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 3-[1-tert-butyloxycarbonyl-5-(1,2,4-triazol-1-yl)pyrrolo[2,3-c]pyridin-3-yl]prop-2-enoate (0.29 g) was hydrogenated over palladium on carbon (10%, 0.435 g) in ethanol (50 mL) at 50 psi of hydrogen for 75 min. The catalyst was removed by filtration and the solvent evaporated in vacuo to give the title compound. (0.24 g) as a colourless solid. This was used without further purification in the next step.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-8b50c08f2153401e95d48742a767375f
Source dataset
uspto-grants-1999_07
Patent number
US05919783

Reaction notes

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