Hydrochloric Acid → HCID 57310684, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(5-(1,2,4-triazol-1-yl)-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)propionate (0.12 g, 0.42 mmol) in methanol (5 mL) was added NaOH (4M, 0.3 mL) and the mixture was heated at 50° C. for 4 hours. After cooling the solution was neutralised (6M, HCl) and the solvents evaporated in uacuo to give 3-(5-(1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)propionic acid (0.65 g) as a yellow solid. This was used without purification in the next step.

Provenance & Evidence