Hydrochloric Acid → HCID 57310684, compound

HRID 580850Notes

Reaction equation

HRID 580850 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]3[CH:14]([CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[CH2:13][NH:12][C:9]3=[CH:10][N:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1.[OH-].[Na+].Cl>CO>[N:1]1([C:6]2[CH:7]=[C:8]3[C:14]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:13][NH:12][C:9]3=[CH:10][N:11]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54308048HCID 54308048, compound

Product 1

HCID 57310684HCID 57310684, compoundYield 601.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of ethyl 3-(5-(1,2,4-triazol-1-yl)-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-3-yl)propionate (0.12 g, 0.42 mmol) in methanol (5 mL) was added NaOH (4M, 0.3 mL) and the mixture was heated at 50° C. for 4 hours. After cooling the solution was neutralised (6M, HCl) and the solvents evaporated in uacuo to give 3-(5-(1,2,4-triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)propionic acid (0.65 g) as a yellow solid. This was used without purification in the next step.

Workup

  1. temperatureAfter cooling the solution
  2. customthe solvents evaporated in uacuo

Sources & evidence

ORD record
ord-c5cf0d642cf74f5b977783ec2aa81bb4
Source dataset
uspto-grants-1999_07
Patent number
US05919783

Reaction notes

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