2-Chloropyridine → 1-(Pyridin-2-yl)piperidin-4-ol

HRID 580854Notes

Reaction equation

HRID 580854 reaction equation
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:8]1[CH2:13][CH2:12][CH:11]([OH:14])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 79772-ChloropyridineHCID 79341Piperidin-4-ol

Product 1

HCID 106074171-(Pyridin-2-yl)piperidin-4-olYield 50%

Procedure

The title compound (3.5 g, 50%) was prepared as a semi solid from 2-chloropyridine (6.7 g) and 4-piperidinol (4 g) by an analogous procedure to that described in preparation 1.

Workup

  1. customthat described in preparation 1

Sources & evidence

ORD record
ord-b57fec47ecc54378983b7b2e295d9055
Source dataset
uspto-grants-1999_07
Patent number
US05919782

Reaction notes

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