反应详情

A mixture of intermediate 1 (37.2 g) and sodium methylate (36 g) in methanol (250 ml) was stirred for 30 min. Ethane iodide (31.2 g) was added dropwise. The reaction mixture was stirred and refluxed for 3 hours. The solvent was evaporated and the residue was stirred in water, filtered and recrystallized from CH3CN. The precipitate was filtered off and dried, yielding 26 g (60%) of 2-(ethylthio)-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone (intermediate 2).

1. stirringThe reaction mixture was stirred
2. temperaturerefluxed for 3 hours
3. customThe solvent was evaporated
4. stirringthe residue was stirred in water
5. filtrationfiltered
6. customrecrystallized from CH3CN
7. filtrationThe precipitate was filtered off
8. customdried