HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → 2-(ethylthio)-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | Ethane;iodide | HCID 18513229 | — |
| Reactant | 5-(2-hydroxyethyl)-6-methyl-2-sulfanyl-1H-pyrimidin-4-one | HCID 178433553 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(ethylthio)-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone | HCID 136174419 | 61% |
Reaction Steps
A mixture of intermediate 1 (37.2 g) and sodium methylate (36 g) in methanol (250 ml) was stirred for 30 min. Ethane iodide (31.2 g) was added dropwise. The reaction mixture was stirred and refluxed for 3 hours. The solvent was evaporated and the residue was stirred in water, filtered and recrystallized from CH3CN. The precipitate was filtered off and dried, yielding 26 g (60%) of 2-(ethylthio)-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone (intermediate 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05919788 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-58e320e6469e409fb1f4545ce0580a3b |
| Source note | uspto-grants-1999_07 |