HRID580907

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)N1CCC(c2ccc3cc(Br)cnc3n2)CC1)NS(=O)(=O)c1ccccc1

HCID86754153

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)N1CCC(c2ccc3c(n2)NCCC3)CC1)NS(=O)(=O)c1ccccc1

HCID86754152

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A solution of bromide 3-6 (125 mg, 0.2021 mmol), 10% Pd/C (125 mg) and EtOH (5 ml) was stirred under 1 atm H2 for 1.0 h. The reaction mixture was then filtered through a celite pad and the filtrate concentrated to give urea 3-7 as a colorless oil.

WORKUP

后处理

filtrationThe reaction mixture was then filtered through a celite pad
concentrationthe filtrate concentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b9ca9e98237749c89ea1a49b6822c851
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05919792
来源说明: uspto-grants-1999_07

反应 SMILES

[C:1]([O:5][C:6](=[O:39])[C@@H:7]([NH:29][S:30]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)(=[O:32])=[O:31])[CH2:8][NH:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:27]=[CH:26][C:25]3[C:20](=[N:21][CH:22]=[C:23](Br)[CH:24]=3)[N:19]=2)[CH2:14][CH2:13]1)=[O:11])([CH3:4])([CH3:3])[CH3:2]>[Pd].CCO>[C:1]([O:5][C:6](=[O:39])[C@@H:7]([NH:29][S:30]([C:33]1[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1)(=[O:31])=[O:32])[CH2:8][NH:9][C:10]([N:12]1[CH2:13][CH2:14][CH:15]([C:18]2[CH:27]=[CH:26][C:25]3[CH2:24][CH2:23][CH2:22][NH:21][C:20]=3[N:19]=2)[CH2:16][CH2:17]1)=[O:11])([CH3:4])([CH3:2])[CH3:3]