4-(6-Bromo-[1,8]naphthyridin-2-yl)piperidin-1-yl-carbonyl-2-(S)-phenylsulfonylamino-beta-alanine t-butyl ester → 4-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)piperidin-1-yl-carbonyl-2-(S)-phenylsulfonylamino-beta-alanine t-butyl ester

Participants

Reaction Steps

A solution of bromide 3-6 (125 mg, 0.2021 mmol), 10% Pd/C (125 mg) and EtOH (5 ml) was stirred under 1 atm H2 for 1.0 h. The reaction mixture was then filtered through a celite pad and the filtrate concentrated to give urea 3-7 as a colorless oil.

Provenance & Evidence