HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → EtOAc EtOH H2O NH4OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)piperidin-1-yl-carbonyl-2-(S)-phenylsulfonylamino-beta-alanine t-butyl ester | HCID 86754152 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | EtOAc EtOH H2O NH4OH | HCID 86752451 | — |
| Product | 4-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)piperidin-1-yl-carbonyl-2-(S)-phenylsulfonylamino-beta-alanine | HCID 86754154 | — |
Reaction Steps
A solution of ester 3-7 (60 mg, 0.1106 mmol), TFA (2 ml) and CH2Cl2 (2 ml) was stirred for 2.0 h. The reaction solution was concentrated and then azeotroped with toluene. Flash chromatography (silica, 25:10:1:1 AE 15:10:1:1 EtOAc/EtOH/NH4OH/H2O) gave acid 3-8 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05919792 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-635a836aa0a14d49a659ffa3f0518d82 |
| Source note | uspto-grants-1999_07 |