HRID580908

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)(C)OC(=O)[C@H](CNC(=O)N1CCC(c2ccc3c(n2)NCCC3)CC1)NS(=O)(=O)c1ccccc1

HCID86754152

未命名化合物

PRODUCTS

生成物

HCID86752451

未命名化合物

结构：O=C(O)[C@H](CNC(=O)N1CCC(c2ccc3c(n2)NCCC3)CC1)NS(=O)(=O)c1ccccc1

HCID86754154

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A solution of ester 3-7 (60 mg, 0.1106 mmol), TFA (2 ml) and CH2Cl2 (2 ml) was stirred for 2.0 h. The reaction solution was concentrated and then azeotroped with toluene. Flash chromatography (silica, 25:10:1:1 AE 15:10:1:1 EtOAc/EtOH/NH4OH/H2O) gave acid 3-8 as a white solid.

WORKUP

后处理

concentrationThe reaction solution was concentrated
customazeotroped with toluene

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-635a836aa0a14d49a659ffa3f0518d82
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05919792
来源说明: uspto-grants-1999_07

反应 SMILES

[C:1]([O:5][C:6](=[O:38])[C@@H:7]([NH:28][S:29]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)(=[O:31])=[O:30])[CH2:8][NH:9][C:10]([N:12]1[CH2:17][CH2:16][CH:15]([C:18]2[CH:27]=[CH:26][C:25]3[CH2:24][CH2:23][CH2:22][NH:21][C:20]=3[N:19]=2)[CH2:14][CH2:13]1)=[O:11])(C)(C)[CH3:2].[C:39](O)([C:41](F)(F)F)=[O:40]>C(Cl)Cl>[CH3:2][CH2:1][O:5][C:6]([CH3:7])=[O:38].[CH3:41][CH2:39][OH:40].[NH4+:9].[OH-:5].[OH2:5].[N:19]1[C:20]2[NH:21][CH2:22][CH2:23][CH2:24][C:25]=2[CH:26]=[CH:27][C:18]=1[CH:15]1[CH2:14][CH2:13][N:12]([C:10]([NH:9][CH2:8][C@H:7]([NH:28][S:29]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)(=[O:30])=[O:31])[C:6]([OH:38])=[O:5])=[O:11])[CH2:17][CH2:16]1