Potassium Carbonate → HCID 54165677, compound

HRID 580916Notes

Reaction equation

HRID 580916 reaction equation
[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([I:12])=[C:4](C)[C:3]=1[C:14](=[O:16])C.C([O-])([O-])=O.[K+].[K+]>CO>[Br:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([I:12])=[CH:4][C:3]=1[CH2:14][OH:16]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 54202784HCID 54202784, compound

Product 1

HCID 54165677HCID 54165677, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 29 (50 mg) in methanol (5 ml) was added 1 ml solution of K2CO3 and the mixture was stirred for 2 hr. at room temperature. The methanol was removed in vacuo and the residue was extracted with methylene chloride (2×50 ml). The methylene chloride fraction was washed with 1N HCl, H2O, brine, dried with anhydrous MgSO4 and evaporated in vacuo to give 40 mg of 30 (90%) as white crystalline solid which upon TLC analysis (silica, hexane/ethyl acetate, 90:10) showed a single component Rf, 0.4.

Workup

  1. customat room temperature
  2. customThe methanol was removed in vacuo
  3. extractionthe residue was extracted with methylene chloride (2×50 ml)
  4. washThe methylene chloride fraction was washed with 1N HCl, H2O, brine
  5. dry with materialdried with anhydrous MgSO4
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-4d9181fb496a4689bbba6cba446c0511
Source dataset
uspto-grants-1999_07
Patent number
US05919797

Reaction notes

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