Water → HCID 67623488, compound

HRID 580923Notes

Reaction equation

HRID 580923 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]3[N:16]([C:17]=2[CH:18]=O)[C:15]2[CH2:20][CH2:21][CH2:22][CH2:23][C:14]=2[S:13]3)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[C:24]([NH:32][NH2:33])(=[O:31])[C:25]1[CH:30]=[CH:29][CH:28]=[N:27][CH:26]=1.[OH-].[K+].O>CO>[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[N:11]=[C:12]3[N:16]([C:17]=2[CH:18]=[N:33][NH:32][C:24]([C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)=[O:31])[C:15]2[CH2:20][CH2:21][CH2:22][CH2:23][C:14]=2[S:13]3)[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

6

Reactant 4

HCID 962WaterHCID 11112Nicotinic acid, hydrazideHCID 14797Potassium HydroxideHCID 15858800HCID 15858800, compound

Product 1

HCID 67623488HCID 67623488, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Next, 0.33 g of 5,6,7,8-tetrahydro-2-(3-nitrophenyl)-3-formylimidazo[2,1-b]benzothiazol, 0.15 g of nicotinohydrazide, and 0.1 g of potassium hydroxide were heated and stirred in 20 ml of methanol at 90° C. for 1.5 hours. After cooling, water was added and the desired substance was obtained in an amount of 0.21 g (yield of 46.7%).

Workup

  1. temperatureAfter cooling
  2. customthe desired substance was obtained in an amount of 0.21 g (yield of 46.7%)

Sources & evidence

ORD record
ord-a906c8b2c5a94183801339f6b90ba210
Source dataset
uspto-grants-1999_07
Patent number
US05919799

Reaction notes

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