反应详情

4 g (8 mmol) of 6-[(4'-trifiuoromethyl-biphenyl-2-carbonyl)-amino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester and 6 ml (78 mmol) of TFA were mixed in 60 ml of methylene chloride for 5 hrs. 40 ml of methylene chloride was added and organic was extracted with 3×50 ml of saturated sodium bicarbonate and brine. Organic layer was dried over sodium sulfate and concentrated to yield 3.1 gm of solid.

1. extractionorganic was extracted with 3×50 ml of saturated sodium bicarbonate and brine
2. dry with materialOrganic layer was dried over sodium sulfate
3. concentrationconcentrated