HRID580935

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66560

1-Naphthalenesulfonyl chloride

C10H7ClO2S

结构：O=C(Nc1ccc2c(c1)CCNC2)c1ccccc1-c1ccc(C(F)(F)F)cc1

HCID11014758

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc2c(c1)CCN(S(=O)(=O)c1cccc3ccccc13)C2)c1ccccc1-c1ccc(C(F)(F)F)cc1

HCID15434259

未命名化合物

PROCEDURE

实验过程

4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide was prepared by METHOD D reacting compound II with naphthalene-1-sulfonyl chloride.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e1fc225dd9b441c7878eb92e21c82d3a
来源数据集: uspto-grants-1999_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05919795
来源说明: uspto-grants-1999_07

反应 SMILES

[CH2:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]([C:14]3[C:15]([C:20]4[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=4)=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:13])=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[C:30]1([S:40](Cl)(=[O:42])=[O:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][CH:31]=1>>[C:30]1([S:40]([N:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[C:7]([NH:11][C:12]([C:14]4[C:15]([C:20]5[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=5)=[CH:16][CH:17]=[CH:18][CH:19]=4)=[O:13])[CH:6]=3)[CH2:1]2)(=[O:42])=[O:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][CH:31]=1