1-Naphthalenesulfonyl chloride → 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide

HRID 580935Notes

Reaction equation

HRID 580935 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][C:7]([NH:11][C:12]([C:14]3[C:15]([C:20]4[CH:25]=[CH:24][C:23]([C:26]([F:29])([F:28])[F:27])=[CH:22][CH:21]=4)=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:13])=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[C:30]1([S:40](Cl)(=[O:42])=[O:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][CH:31]=1>>[C:30]1([S:40]([N:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[C:7]([NH:11][C:12]([C:14]4[C:15]([C:20]5[CH:25]=[CH:24][C:23]([C:26]([F:27])([F:28])[F:29])=[CH:22][CH:21]=5)=[CH:16][CH:17]=[CH:18][CH:19]=4)=[O:13])[CH:6]=3)[CH2:1]2)(=[O:42])=[O:41])[C:39]2[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 665601-Naphthalenesulfonyl chlorideHCID 110147584'-Trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4tetrahydroisoquinolin-6-yl)-amide

Product 1

HCID 154342594'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide

Procedure

4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide was prepared by METHOD D reacting compound II with naphthalene-1-sulfonyl chloride.

Sources & evidence

ORD record
ord-e1fc225dd9b441c7878eb92e21c82d3a
Source dataset
uspto-grants-1999_07
Patent number
US05919795

Reaction notes

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