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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 580935Generated: October 25, 2026

1-Naphthalenesulfonyl chloride → 4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide

https://huagongshe.com/reaction/580935

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Naphthalenesulfonyl chlorideHCID 66560—
Reactant4'-Trifluoromethyl-biphenyl-2-carboxylic acid (1,2,3,4tetrahydroisoquinolin-6-yl)-amideHCID 11014758—
Product4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amideHCID 15434259—

Reaction Steps

4'-Trifluoromethyl-biphenyl-2-carboxylic acid [2-(naphthalene-1-sulfonyl)-1,2,3,4-tetrahydroisoquinolin6-yl]-amide was prepared by METHOD D reacting compound II with naphthalene-1-sulfonyl chloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05919795
Source datasetuspto-grants-1999_07
ORD IDord-e1fc225dd9b441c7878eb92e21c82d3a
Source noteuspto-grants-1999_07