Hydrochloric Acid → HCID 21310030, compound

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Reaction Steps

From 3{tert-Butoxycarbonyl-[2-(1-propoxy)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-amino}-[2S,3S]-2-phenylpiperidine-1-carboxylic acid tert-butyl ester (268 mg, 0.4 mmol) using 4M-hydrogen chloride in dioxan (2 ml) to give the title compound as a white solid (93 mg). Found C, 51.04; H, 5.52; N, 15.24; C23H27F3N6O.2HCl.0.4H2O (540.64) requires C, 51.10; H, 5.56; N, 15.54%. Mass spectrum (thermospray +ve) m/e 461 (MH+).

Provenance & Evidence