Hydrochloric Acid → HCID 21310030, compound

HRID 580948Notes

Reaction equation

HRID 580948 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([N:14](C(OC(C)(C)C)=O)[CH2:15][C:16]2[CH:21]=[C:20]([N:22]3[C:26]([C:27]([F:30])([F:29])[F:28])=[N:25][N:24]=[N:23]3)[CH:19]=[CH:18][C:17]=2[O:31][CH2:32][CH2:33][CH3:34])[C@@H:9]1[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=O)(C)(C)C.[ClH:48]>O1CCOCC1>[ClH:48].[ClH:48].[CH2:32]([O:31][C:17]1[CH:18]=[CH:19][C:20]([N:22]2[C:26]([C:27]([F:29])([F:28])[F:30])=[N:25][N:24]=[N:23]2)=[CH:21][C:16]=1[CH2:15][NH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]1[C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)[CH2:33][CH3:34]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86754174HCID 86754174, compound

Product 1

HCID 21310030HCID 21310030, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

From 3{tert-Butoxycarbonyl-[2-(1-propoxy)-5-(5-trifluoromethyl-tetrazol-1-yl)-benzyl]-amino}-[2S,3S]-2-phenylpiperidine-1-carboxylic acid tert-butyl ester (268 mg, 0.4 mmol) using 4M-hydrogen chloride in dioxan (2 ml) to give the title compound as a white solid (93 mg). Found C, 51.04; H, 5.52; N, 15.24; C23H27F3N6O.2HCl.0.4H2O (540.64) requires C, 51.10; H, 5.56; N, 15.54%. Mass spectrum (thermospray +ve) m/e 461 (MH+).

Sources & evidence

ORD record
ord-9c06e234932444d3b11dce0327afebbc
Source dataset
uspto-grants-1999_07
Patent number
US05919803

Reaction notes

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