Isopropyl isocyanate → HCID 14627711, compound

HRID 581027Notes

Reaction equation

HRID 581027 reaction equation
[CH3:1][C:2]1([CH3:17])[O:14][C:6]2=[CH:7][C:8]3[C:9]([CH:13]=[C:5]2[CH:4]([NH2:15])[CH:3]1[OH:16])=[N:10][O:11][N:12]=3.[CH:18]([N:21]=[C:22]=[O:23])([CH3:20])[CH3:19]>ClCCl>[CH3:1][C:2]1([CH3:17])[O:14][C:6]2=[CH:7][C:8]3[C:9]([CH:13]=[C:5]2[CH:4]([NH:15][C:22]([NH:21][CH:18]([CH3:20])[CH3:19])=[O:23])[CH:3]1[OH:16])=[N:10][O:11][N:12]=3

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 11107308(+)-7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano[2,3-f]benz-2,1,3-oxadiazole

Product 1

HCID 14627711HCID 14627711, compoundYield 44.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

200 mg (0.850 mmol) of 7,8-dihydro-6,6-dimethyl-7-hydroxy-8-amino-6H-pyrano[2,3-f]benzo-2,1,3-oxadiazole and 20 ml of dichloromethane were stirred at room temperature, and 92 μl (0.935 mmol) of isopropyl isocyanate were added thereto and stirred for 6 hours. The crystals precipitated were filtered off to obtain 120 mg of the intended compound as colorless crystals. (yield: 44%)

Workup

  1. customThe crystals precipitated
  2. filtrationwere filtered off

Sources & evidence

ORD record
ord-35ed50479c1b4fcd9ef13176776fc47a
Source dataset
uspto-grants-1999_07
Patent number
US05919806

Reaction notes

Loading…