Potassium Iodide → HCID 86754176, compound

Participants

Reaction Steps

Replacement of the bromine of the compound obtained in Step A is carried out in dimethylformamide (10 ml) under an argon atmosphere in the presence of potassium phthalimide (1.5 eq.) catalysed by potassium iodide (0.07 eq.). The reaction mixture is stirred and heated at reflux for 3 hours. The residual and resulting salts are removed by filtration; the product is then precipitated in the cold by the addition of water to the filtrate. The solid formed is filtered and then dried in vacuo in the presence of phosphorus pentoxide.

Provenance & Evidence