Potassium Iodide → HCID 86754176, compound

HRID 581066Notes

Reaction equation

HRID 581066 reaction equation
BrBr.Br[CH2:4][CH2:5][O:6][C:7]1[C:16]2[O:15][CH2:14][CH2:13][O:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.[C:17]1(=[O:27])[NH:21][C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.[K].[I-].[K+]>CN(C)C=O>[O:12]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([O:6][CH2:5][CH2:4][N:21]3[C:17](=[O:27])[C:18]4[C:19](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:20]3=[O:22])[C:16]=2[O:15][CH2:14][CH2:13]1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 24408BromineHCID 27355665-(2-bromoethoxy)-2,3-dihydro-1,4-benzodioxineHCID 24194345Phthalimide potassium salt

Product 1

HCID 86754176HCID 86754176, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Replacement of the bromine of the compound obtained in Step A is carried out in dimethylformamide (10 ml) under an argon atmosphere in the presence of potassium phthalimide (1.5 eq.) catalysed by potassium iodide (0.07 eq.). The reaction mixture is stirred and heated at reflux for 3 hours. The residual and resulting salts are removed by filtration; the product is then precipitated in the cold by the addition of water to the filtrate. The solid formed is filtered and then dried in vacuo in the presence of phosphorus pentoxide.

Workup

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. customThe residual and resulting salts
  4. customare removed by filtration
  5. customthe product is then precipitated in the cold by the addition of water to the filtrate
  6. customThe solid formed
  7. filtrationis filtered
  8. dry with materialdried in vacuo in the presence of phosphorus pentoxide

Sources & evidence

ORD record
ord-c0bd2d2f8cdd4fbd9e58c430d403aea5
Source dataset
uspto-grants-1999_07
Patent number
US05919814

Reaction notes

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