反应详情

温度

70 °C

In a 500 mL pear flask equipped with a magnetic stir bar were mixed (R)-pyrrolidin-3-ol hydrochloride (8.94 g, 72.3 mmol), 5-bromo-2-chloro-4-methylpyrimidine (15 g, 72.3 mmol), DIPEA (31.6 mL, 181 mmol), and EtOH (150 mL). The resulting yellow suspension was heated in a sand bath to 70° C. for 18 hours. At this time about half of the solvent was evaporated. Water (250 mL) was added to the flask while rapidly stirring the solution. An off-white precipitate formed and was filtered off, washed with water (100 mL) and dried to give the title compound (16.7 g, 89.5%).

1. customIn a 500 mL pear flask equipped with a magnetic stir bar
2. customAt this time about half of the solvent was evaporated
3. additionWater (250 mL) was added to the flask
4. customAn off-white precipitate formed
5. filtrationwas filtered off
6. washwashed with water (100 mL)
7. customdried