反应详情

温度

100 °C

A degassed mixture of (6-chloro-pyrimidin-4-yl)-pyridin-3-ylmethyl-amine (300 g, 1.36 mmol), 2-nitro-phenylamine (188 g, 1.36 mmol), Pd2(dba)3 (128 g, 0.14 mmol), Xantphos (161 g, 0.28 mmol) and Cs2CO3 (913 g, 2.8 mmol) in toluene (10 mL) was heated at 100° C. for 4 hours. The reaction was concentrated, and the residue was purified by flash chromatography on silica to obtain the title compound (150 mg, yield: 34%). MS (ESI): 323 [M+H]+.

1. concentrationThe reaction was concentrated
2. customthe residue was purified by flash chromatography on silica