反应详情

温度

46 °C

15-Acetoxy-pentadecanoyl chloride (151 g; 0.47 mole) was added to a stirred mixture of 1-morpholino-cyclododecene (133 g; 0.53 mole) and chloroform (500 ml, free of alcohol) under nitrogen during 35 minutes. The temperature raised to 46° C. After stirring for 2 hours a mixture of 82 ml of water and 125 ml of hydrochloric acid (36%) was added and this mixture was refluxed for 4 hours at 62° C. After cooling the flask to room temperature the layers were separated and the organic ##STR6## layer was washed with 250 ml of 1N hydrochloric acid. The water layer was extracted with 100 ml of chloroform. The combined chloroform layers were concentrated giving 240 g of crude (15-acetoxy-pentadecanoyl)-cyclododecanone.

1. additionwas added
2. temperaturethis mixture was refluxed for 4 hours at 62° C
3. temperatureAfter cooling the flask to room temperature the layers
4. customwere separated
5. washthe organic ##STR6## layer was washed with 250 ml of 1N hydrochloric acid
6. extractionThe water layer was extracted with 100 ml of chloroform
7. concentrationThe combined chloroform layers were concentrated