Hydrochloric Acid → HCID 86754190, compound

HRID 581701Notes

Reaction equation

HRID 581701 reaction equation
[CH3:1][C:2]1([CH2:17][C:18]([O:20]CC)=[O:19])[C:16]2[C:6]([CH:7]=[C:8]3[NH:13][C:12](=[O:14])[C:11](=[O:15])[NH:10][C:9]3=2)=[CH:5][CH:4]=[CH:3]1.Cl>O1CCOCC1>[CH3:1][C:2]1([CH2:17][C:18]([OH:20])=[O:19])[C:16]2[C:6]([CH:7]=[C:8]3[NH:13][C:12](=[O:14])[C:11](=[O:15])[NH:10][C:9]3=2)=[CH:5][CH:4]=[CH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86754191HCID 86754191, compound

Product 1

HCID 86754190HCID 86754190, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
40 °C

Procedure

A mixture of 0.7 g of ethyl (5-methyl-2,3-dioxo-1,4-dihydro-5H-indeno [1,2-b]pyrazin-5-yl)acetate, 40 ml of dioxane and 9 ml of 8N hydrochloric acid is heated to 40° C. for 90 hours. The reaction mixture is then evaporated in a rotary evaporator, and the evaporation residue is triturated in 20 ml of water, filtered off and rinsed with distilled water (2×10 ml) and then with isopropyl ether (10 ml). After drying at 60° C. under vacuum (1 mm Hg; 0.13 kPa), 0.4 g of (5-methyl-2,3-dioxo-1,4-dihydro-5H-indeno [1,2-b]pyrazin-5-yl)acetic acid is obtained in the form of a pale yellow solid melting above 260° C. (Analysis % calculated C: 61.76; H: 4.44; N: 10.29; 0: 23.51; % found C: 61.8; H: 4.6; N: 10.4).

Workup

  1. customThe reaction mixture is then evaporated in a rotary evaporator
  2. customthe evaporation residue is triturated in 20 ml of water
  3. filtrationfiltered off
  4. washrinsed with distilled water (2×10 ml)
  5. customAfter drying at 60° C. under vacuum (1 mm Hg; 0.13 kPa)

Sources & evidence

ORD record
ord-af1de95396424bd184aecc28490b2108
Source dataset
uspto-grants-1999_07
Patent number
US05922716

Reaction notes

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