HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-{[[4-[3-(4-Phenylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Phenylpiperazine | HCID 7096 | — |
| Reactant | HCID 54054490 | HCID 54054490 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-{[[4-[3-(4-Phenylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride | HCID 86754205 | 73% |
Reaction Steps
According to the procedure indicated in Examples 1), 3) and 6), reaction of 2-{[[4-(3-chloropropylthio)-3-methoxy-2-pyridinyl]methyl]thio}-1H-benzimidazole with N-phenylpiperazine and subsequent conversion into the hydrochloride in acetone gives the title compound; colorless crystals; m.p. 105° C., dec.; yield 73%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05922720 |
| Source dataset | uspto-grants-1999_07 |
| ORD ID | ord-9aa1337e3c17466684492591fcd2abcf |
| Source note | uspto-grants-1999_07 |