Hydrochloric Acid → 2-{[[4-[3-(4-Phenylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochloride

HRID 581739Notes

Reaction equation

HRID 581739 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[NH:18][C:17]3[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=3[N:15]=2)[C:7]=1[O:23][CH3:24].[C:25]1([N:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.[ClH:37]>CC(C)=O>[ClH:1].[ClH:37].[ClH:1].[C:25]1([N:31]2[CH2:36][CH2:35][N:34]([CH2:2][CH2:3][CH2:4][S:5][C:6]3[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]4[NH:18][C:17]5[CH:19]=[CH:20][CH:21]=[CH:22][C:16]=5[N:15]=4)[C:7]=3[O:23][CH3:24])[CH2:33][CH2:32]2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 70961-PhenylpiperazineHCID 54054490HCID 54054490, compound

Product 1

HCID 867542052-{[[4-[3-(4-Phenylpiperazin-1-yl)propylthio]-3-methoxy-2-pyridinyl]-methyl]thio}-1H-benzimidazole trihydrochlorideYield 73%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

According to the procedure indicated in Examples 1), 3) and 6), reaction of 2-{[[4-(3-chloropropylthio)-3-methoxy-2-pyridinyl]methyl]thio}-1H-benzimidazole with N-phenylpiperazine and subsequent conversion into the hydrochloride in acetone gives the title compound; colorless crystals; m.p. 105° C., dec.; yield 73%.

Sources & evidence

ORD record
ord-9aa1337e3c17466684492591fcd2abcf
Source dataset
uspto-grants-1999_07
Patent number
US05922720

Reaction notes

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