Sodium Hydroxide → HCID 53739331, compound

HRID 581743Notes

Reaction equation

HRID 581743 reaction equation
[SH:1][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[N:3]=1.Cl.[Cl:12][CH2:13][CH2:14][S:15][C:16]1[CH:21]=[CH:20][N:19]=[C:18]([CH2:22]Cl)[C:17]=1[CH3:24].[OH-].[Na+]>>[Cl:12][CH2:13][CH2:14][S:15][C:16]1[CH:21]=[CH:20][N:19]=[C:18]([CH2:22][S:1][C:2]2[NH:6][C:5]3[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=3[N:3]=2)[C:17]=1[CH3:24]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 18404153HCID 18404153, compoundHCID 178527775HCID 178527775, compound

Product 1

HCID 53739331HCID 53739331, compound

Procedure

According to the procedure indicated in Example A1, reaction of 2-mercapto-1H-benzimidazole with 4-(2-chloroethylthio)-2-chloromethyl-3-methylpyridine hydrochloride and NaOH gives, after crystallization from ethyl acetate, the title compound (62% of theory) as a colorless solid of m.p. 178-180° C.

Workup

  1. customgives
  2. customafter crystallization from ethyl acetate

Sources & evidence

ORD record
ord-b2a13a6151d142fea86b7228220bea59
Source dataset
uspto-grants-1999_07
Patent number
US05922720

Reaction notes

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