Triethylamine → HCID 5202381, compound

HRID 581786Notes

Reaction equation

HRID 581786 reaction equation
OCC[C:4]12[CH:14]=[CH:13][CH:12]=[CH:11][CH:5]1[C:6]([NH:8][C:9]2=[O:10])=[O:7].C([N:17]([CH2:20]C)[CH2:18]C)C.CN=C=[O:25].[O:26]1CCO[CH2:28][CH2:27]1>>[CH3:20][NH:17][C:18](=[O:25])[O:26][CH2:27][CH2:28][N:8]1[C:6](=[O:7])[C:5]2=[CH:11][CH:12]=[CH:13][CH:14]=[C:4]2[C:9]1=[O:10]

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 312751,4-DioxaneHCID 22113084HCID 22113084, compound

Product 1

HCID 5202381HCID 5202381, compound

Procedure

To a suspension of 2-(2-hydroxyethyl)phthalimide (10.0 g) and triethylamine (0.729 ml) in 1,4-dioxane (50 ml) was added methyl isocyanate (4.63 ml) under ice-bath cooling, and the mixture was stirred for 4 days at ambient temperature. The solvent was removed in vacuo, and the residue was recrystallized with methanol to give 2-phthalimidoethyl methylcarbamate (10.13 g). mp 142.3-145.0° C.

Workup

  1. temperaturecooling
  2. customThe solvent was removed in vacuo
  3. customthe residue was recrystallized with methanol

Sources & evidence

ORD record
ord-f0ec8aeacca14eadb724bce7a6f5b1c2
Source dataset
uspto-grants-1999_07
Patent number
US05922711

Reaction notes

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