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Hydrochloric Acid → 4-Cyano-4-(2-methylphenyl)piperidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | tert-Butyl 4-cyano-4-(2-methylphenyl)piperidine-1-carboxylate | HCID 22625983 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-Cyano-4-(2-methylphenyl)piperidine hydrochloride | HCID 21712248 | — |
反応手順
A solution of EtOAc saturated with HCl (200 ml) was added to 4-cyano-N-(1,1 -dimethylethoxy)carbonyl-4-(2-methylphenyl)piperidine (31 mg, 0.097 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-cyano-4-(2-methylphenyl)piperidine hydrochloride (4i) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05922722 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-0f6ad8944cab43efbd8749bc4dec99e7 |
| 出典メモ | uspto-grants-1999_07 |