Hydrochloric Acid → 4-Cyano-4-(2-methylphenyl)piperidine hydrochloride

HRID 581804Notes

Reaction equation

HRID 581804 reaction equation
[ClH:1].[C:2]([C:4]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])[CH2:9][CH2:8][N:7](C(OC(C)(C)C)=O)[CH2:6][CH2:5]1)#[N:3]>CCOC(C)=O>[ClH:1].[C:2]([C:4]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)#[N:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22625983tert-Butyl 4-cyano-4-(2-methylphenyl)piperidine-1-carboxylate

Product 1

HCID 217122484-Cyano-4-(2-methylphenyl)piperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of EtOAc saturated with HCl (200 ml) was added to 4-cyano-N-(1,1 -dimethylethoxy)carbonyl-4-(2-methylphenyl)piperidine (31 mg, 0.097 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-cyano-4-(2-methylphenyl)piperidine hydrochloride (4i) as a white solid.

Workup

  1. customto react for 1 hour at room temperature
  2. customThe EtOAc was removed in vacuo

Sources & evidence

ORD record
ord-0f6ad8944cab43efbd8749bc4dec99e7
Source dataset
uspto-grants-1999_07
Patent number
US05922722

Reaction notes

Loading…