HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl bromoacetate → 4-[2-(Carboxy)-ethyl]-1-[(cyclohexyloxycarbonyl)-methyl]-pipe-ridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl bromoacetate | HCID 7748 | — |
| Edukt | Cyclohexanol | HCID 7966 | — |
| Edukt | Bromoacetyl chloride | HCID 89602 | — |
| Edukt | Cyclohexyl bromoacetate | HCID 221279 | — |
| Edukt | Pyridine ethyl acetate | HCID 21992828 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Produkt | 4-[2-(Carboxy)-ethyl]-1-[(cyclohexyloxycarbonyl)-methyl]-pipe-ridine | HCID 21198532 | — |
Reaktionsschritte
The preparation is carried out analogously to Examples XLIIa to c. Instead of ethyl bromoacetate, cyclohexyl bromoacetate (boiling point: 102-104° C. under 16 mbar, prepared by reaction of bromoacetyl chloride with cyclohexanol in pyridine/ethyl acetate in the presence of a catalytic amount of 4-dimethylaminopyridine) is employed. Melting point: 85-88° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05922717 |
| Quelldatensatz | uspto-grants-1999_07 |
| ORD ID | ord-5088b1b3b0764c0590b0d72d77f1131b |
| Quellennotiz | uspto-grants-1999_07 |