Hydrochloric Acid → HCID 86754215, compound

Participants

Reaction Steps

8.5 mg (0.22 mmol) of sodium borohydride are added to a solution of 100 mg (0.22 mmol) of 4-[[4-(4-piperidinyl)-piperazin-1yl]acetyl]phenoxyacetic acid trihydrochloride in 10 ml of methanol and the mixture is stirred overnight. 2 ml of a 0.1N hydrochloric acid are then added and the solution is concentrated to dryness under reduced pressure. The residue is partitioned between saturated sodium chloride solution and ethyl acetate and, after drying over sodium sulphate, the organic phase is concentrated to dryness. Mass spectrum: (M+H)+ =364;

Provenance & Evidence