Hydrochloric Acid → HCID 86754215, compound

HRID 581846Notes

Reaction equation

HRID 581846 reaction equation
[BH4-].[Na+].[ClH:3].Cl.Cl.[NH:6]1[CH2:11][CH2:10][CH:9]([N:12]2[CH2:17][CH2:16][N:15]([CH2:18][C:19]([C:21]3[CH:31]=[CH:30][C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:23][CH:22]=3)=O)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1.Cl.C[OH:34]>>[ClH:3].[ClH:3].[NH:6]1[CH2:11][CH2:10][CH:9]([N:12]2[CH2:17][CH2:16][N:15]([CH:18]([OH:34])[CH2:19][C:21]3[CH:31]=[CH:30][C:24]([O:25][CH2:26][C:27]([OH:29])=[O:28])=[CH:23][CH:22]=3)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 4311764Sodium borohydrideHCID 86754217HCID 86754217, compound

Product 1

HCID 86754215HCID 86754215, compound

Procedure

8.5 mg (0.22 mmol) of sodium borohydride are added to a solution of 100 mg (0.22 mmol) of 4-[[4-(4-piperidinyl)-piperazin-1yl]acetyl]phenoxyacetic acid trihydrochloride in 10 ml of methanol and the mixture is stirred overnight. 2 ml of a 0.1N hydrochloric acid are then added and the solution is concentrated to dryness under reduced pressure. The residue is partitioned between saturated sodium chloride solution and ethyl acetate and, after drying over sodium sulphate, the organic phase is concentrated to dryness. Mass spectrum: (M+H)+ =364;

Workup

  1. concentrationthe solution is concentrated to dryness under reduced pressure
  2. customThe residue is partitioned between saturated sodium chloride solution and ethyl acetate
  3. dry with materialafter drying over sodium sulphate
  4. concentrationthe organic phase is concentrated to dryness

Sources & evidence

ORD record
ord-46c20bc2c5c74b4991debc39f24c0d03
Source dataset
uspto-grants-1999_07
Patent number
US05922717

Reaction notes

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