3-(2-Bromoethyl)cyclopent-1-ene → 1-(2-Cyclopent-2-en-1-ylethyl)-6-(3,5-dimethylbenzoyl)-5-isopropyl-pyrimidine-2,4-dione

HRID 581885Notes

Reaction equation

HRID 581885 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[CH:22]1([CH2:27][CH2:28]Br)[CH2:26][CH2:25][CH:24]=[CH:23]1>>[CH:22]1([CH2:27][CH2:28][N:8]2[C:9]([C:10](=[O:19])[C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]2=[O:20])[CH2:26][CH2:25][CH:24]=[CH:23]1

Participants

3

Reactant 2

HCID 126588663-(2-Bromoethyl)cyclopent-1-eneHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 4834941-(2-Cyclopent-2-en-1-ylethyl)-6-(3,5-dimethylbenzoyl)-5-isopropyl-pyrimidine-2,4-dioneYield 32.3%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2-(cyclopent-2-en-1-yl)ethyl bromide were reacted by the same method with example 40 to obtain the titled compound (123 mg).

Sources & evidence

ORD record
ord-ee92c283b7e1430cb09fe4025f7ca6a6
Source dataset
uspto-grants-1999_07
Patent number
US05922727

Reaction notes

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